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Comparison of masking agents for antimony speciation analysis using hydride generation atomic fluorescence

Jianhong XI,Mengchang HE,Kunpeng WANG,Guizhi ZHANG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 970-978 doi: 10.1007/s11783-014-0716-3

Abstract: For the determination of Sb(III), four compounds were tested as masking agents to inhibit the generationThe effects of the concentrations of the masking agents and of HCl on the fluorescence signals from Sb

Keywords： Sb(III)     Sb(V)     determination     masking agents     hydride generation (HG-AFS)    

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Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1631-2

Abstract:

● All 1,4-naphthoquinone hybrids exhibited significant antimicrobial activity.

Keywords： 1     4-naphthoquinone derivatives     Antibacterial     Action mechanism     RecA    

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Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 112-120 doi: 10.1007/s11705-021-2075-5

Abstract: The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporatedNotably, these compounds can directly serve as both reporting and imaging agents in vitro andin vivo without the need to add other fluorescent tagging agents.

Keywords： fluorescent drug     lysosomal     anticancer     zebrafish     nude-mouse tumour imaging    

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Screening of textile finishing agents available on the Chinese market: An important source of per- and

Mehvish Mumtaz, Yixiang Bao, Wenchao Li, Lingxiao Kong, Jun Huang, Gang Yu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 5, doi: 10.1007/s11783-019-1145-0

Abstract: Kendrick mass defect was used for PFASs screening in textile finishing agents (TFAs).Organofluorinated surfactants are widely employed in textile finishing agents (TFAs) to achieve oil,

Keywords： Textile finishing agents     Kendrick mass defect     Total oxidizable precursor assay    

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Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2101-2113 doi: 10.1007/s11705-023-2361-5

Abstract: Overall, we developed the promising antimicrobial agents that destroyed the redox system of phytopathogenic

Keywords： ursolic acid     antibacterial activities     reactive oxygen species     apoptosis    

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Discovery of cryptolepine derivatives as novel promising agents against phytopathogenic bacteria

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 156-166 doi: 10.1007/s11705-022-2196-5

Abstract: To ensure the production of food crops, a series of cryptolepine derivatives were synthesised, after which their antibacterial activities and mechanism of action against three plant pathogens were investigated. Our bioassay results indicated that most of the target compounds displayed potent inhibitory effects against Xanthomonas oryzae (X. oryzae) and Xanthomonas axonopodis pv. citri (X. axonopodis pv. c.). Remarkably, compound 9 exhibited the best in vitro antibacterial activity against X. oryzae, with a minimum inhibitory concentration (MIC) value of 0.78 μg·mL–1. Compound 2 exhibited the best in vitro antibacterial activity against X. axonopodis pv. c., with an MIC value of 0.39 μg·mL–1. These activities were superior to those of copper quinolate (MIC = 6.25, 25 μg·mL–1) and thiodiazole copper (MIC = 100, 200 μg·mL–1) against X. oryzae and X. axonopodis pv. c. In vivo experiments demonstrated the promising applicability of compound 9 for the control of rice bacterial infections. Furthermore, compound 9 was selected as a candidate to conduct preliminary analyses of the antibacterial mechanisms of cryptolepine derivatives. Scanning electron microscopy and transmission electron microscopy observations, extracellular polysaccharide production, biofilm formation, transcriptomic, quantitative reverse transcription-polymerase chain reaction analyses, and molecular docking assays were performed. Collectively, our findings demonstrated that compound 9 might act via multifarious mechanisms to down-regulate virulence factors and cause cell death.

Keywords： cryptolepine derivatives     phytopathogenic bacteria     antibacterial activity     mechanism of action    

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BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 82-97 doi: 10.15302/J-FASE-2021404

Abstract:

Bioinsecticides are naturally-occurring substances from different sources that control insect pests. Ideal bioinsecticides should have low toxicity to non-target organisms. They should also be easily degraded in sewage treatment works and natural environments, highly effective in small quantities and affect target pests only. Public concerns about possible side-effects of synthetic pesticides have accelerated bioinsecticide research and development. However, to develop bioinsecticides into mainstream products, their high production costs, short shelf-life and often uncertain modes of action need to be considered. This review summarizes current progress on bioinsecticides which are categorized as biochemical insecticides and their derivatives, plant-incorporated protectants, and microbial bioinsecticides. The current constraints that prevent bioinsecticides from being widely used are discussed and future research directions are proposed.

 

Keywords： biochemical insecticide / bioinsecticide / microbial bioinsecticides / plant-incorporated protectant / RNA insecticide    

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Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 517-521 doi: 10.1007/s11684-016-0480-9

Abstract:

This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium

Keywords： antimicrobial susceptibility/resistance     Propionibacterium acnes     topical antibiotics     in vitro study    

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Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 46-56 doi: 10.1007/s11684-015-0375-1

Abstract:

Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vaso-occlusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is increasingly recognized as an important intermediate in these pathophysiological processes and is therefore an important target for therapeutic intervention. The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeutic intent. This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. A brief overview of oxidative stress in the clinical context of SCD is accompanied by a discussion of several pathophysiological mechanisms contributing to oxidative stress. Finally, these mechanisms are then related to current management strategies in SCD that are either utilized currently or under evaluation. The article concludes with a perspective on the potential of the various therapeutic interventions to reduce oxidative stress and morbidity associated with SCD.

Keywords： oxidative stress     Nrf2     triterpenoids     sickle cell disease     vaso-occlusion     CDDO-Me    

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Self-supervised graph learning with target-adaptive masking for session-based recommendation Research Article

Yitong WANG, Fei CAI, Zhiqiang PAN, Chengyu SONG,wangyitong20@nudt.edu.cn,caifei08@nudt.edu.cn,panzhiqiang@nudt.edu.cn,songchengyu@nudt.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 1,   Pages 73-87 doi: 10.1631/FITEE.2200137

Abstract: aims to predict the next item based on a user's limited interactions within a short period. Existing approaches use mainly recurrent neural networks (RNNs) or (GNNs) to model the sequential patterns or the transition relationships between items. However, such models either ignore the over-smoothing issue of GNNs, or directly use cross-entropy loss with a softmax layer for model optimization, which easily results in the over-fitting problem. To tackle the above issues, we propose a self-supervised graph learning with (SGL-TM) method. Specifically, we first construct a global graph based on all involved sessions and subsequently capture the self-supervised signals from the global connections between items, which helps supervise the model in generating accurate representations of items in the ongoing session. After that, we calculate the main supervised loss by comparing the ground truth with the predicted scores of items adjusted by our designed module. Finally, we combine the main supervised component with the auxiliary self-supervision module to obtain the final loss for optimizing the model parameters. Extensive experimental results from two benchmark datasets, Gowalla and Diginetica, indicate that SGL-TM can outperform state-of-the-art baselines in terms of Recall@20 and MRR@20, especially in short sessions.

Keywords： Session-based recommendation     Self-supervised learning     Graph neural networks     Target-adaptive masking    

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Self-etching adhesives: possible new pulp capping agents to vital pulp therapy

Chun CUI, Xiu-Neng ZHOU, Wei-Min CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 77-79 doi: 10.1007/s11684-010-0104-8

Abstract:

Pulp capping is one of the solving for keeping vital pulp in the case of dentin caries, reversible pulpitis or traumatic pulp exposure. The presence of bacteria on the cavity walls or in the pulp was the major factor that leads to the failure of pulp capping. Traditional pulp capping agent, calcium hydroxide, may not prevent microleakage. Self-etching system is a newly developed adhesive system, which could provide less microleakage and would not break down or dissolve, preventing the oral fluids and bacteria from the pulp along the cavity wall. This may reduce such clinical problems as postoperative sensitivity, secondary caries and marginal discoloration. Researches showed that some kinds of self-etching adhesives induced the mild to moderate inflammatory pulp response, with negative bacterial staining. Inclusion of antibacterial components into self-etching system, such as 12- methacryloyloxydodecylpyridinium bromide (MDPB) may inhibit bacteria and provide better clinical effects. It is speculated that using the self-etching adhesive system containing the antibacterial agent, such as MDPB, to the dental pulp directly or indirectly, may inhibit bacteria after the placement of restoration as well as residual bacteria in the cavity.

Keywords： dental pulp     pulp capping     self-etching adhesives     antibacterial components    

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Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey

N.V. Vasilyeva, E.R. Raush, M.V. Rudneva, T.S. Bogomolova, A.E. Taraskina, Yong Fang, Fengmin Zhang, N.N. Klimko

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 84-91 doi: 10.1007/s11684-017-0612-x

Abstract:

A multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was

Keywords： prevalence     &Scy     andida species     invasive candidosis     nosocomial     etiology     MALDI-TOF mass-spectrometry     candidemia    

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Coach-assisted multi-agent reinforcement learning framework for unexpected crashed agents Research Article

Jian ZHAO, Youpeng ZHAO, Weixun WANG, Mingyu YANG, Xunhan HU, Wengang ZHOU, Jianye HAO, Houqiang LI

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 7,   Pages 1032-1042 doi: 10.1631/FITEE.2100594

Abstract: One reason for the gap is that simulated systems always assume that agents can work normally all thetime, while in practice, one or more agents may unexpectedly "crash" during the coordination processSuch crashes destroy the cooperation among agents and lead to performance degradation.

Keywords： Multi-agent system     Reinforcement learning     Unexpected crashed agents    

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preliminary version was presented at the 13th International Conference on Practical Applications of Agents

J. A. RINCON,J. BAJO,A. FERNANDEZ,V. JULIAN,C. CARRASCOSA

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 4,   Pages 325-337 doi: 10.1631/FITEE.1500343

Abstract: Human-agent societies refer to applications where virtual agents and humans coexist and interact transparentlyOne of the most important aspects in this kind of applications is including emotional states of the agents

Keywords： Multi-agent systems     Virtual environments     Emotional agents    

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Safety issues of methylglyoxal and potential scavengers

Shiming LI, Siyu LIU, Chi-Tang HO

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 312-320 doi: 10.15302/J-FASE-2017174

Abstract:

The health safety of methylglyoxal (MGO) has been recognized as a key issue owing to its ultra-high reactivity toward some key biomolecules such as amino acids, proteins, DNA, sulfhydryl- and basic nitrogen-containing compounds, including amino-bearing neurotransmitters. In this review, we have summarized the endo- and exogenous sources of MGO and its accumulation inside the body due to high intake, abnormal glucose metabolism and or malfunctioning glyoxalases, and review the debate concerning the adverse functionality of MGO ingested from foods. Higher than normal concentrations of MGO in the circulatory system and tissues have been found to be closely associated with the production of advanced glycation end products (AGEs), increased oxidative stress, elevated inflammation and RAGE (AGE receptors) activity, which subsequently progresses to a pathological stage of human health, such as diabetes complications, cancer, cardiovascular and degenerative diseases. Having illustrated the mechanisms of MGO trapping in vivo, we advocate the development of efficient and efficacious MGO scavengers, either assisting or enhancing the activity of endogenous glyoxalases to facilitate MGO removal, or providing phytochemicals and functional foods containing them, or pharmaceuticals to irreversibly bind MGO and thus form MGO-complexes that are cleared from the body.

Keywords： reactive carbonyl species     advanced glycation end products     diabetes     brain health     methylglyoxal trapping agents    

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Title Author Date Type Operation

Comparison of masking agents for antimony speciation analysis using hydride generation atomic fluorescence

Jianhong XI,Mengchang HE,Kunpeng WANG,Guizhi ZHANG

Journal Article

Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies

Journal Article

Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Journal Article

Screening of textile finishing agents available on the Chinese market: An important source of per- and

Mehvish Mumtaz, Yixiang Bao, Wenchao Li, Lingxiao Kong, Jun Huang, Gang Yu

Journal Article

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Journal Article

Discovery of cryptolepine derivatives as novel promising agents against phytopathogenic bacteria

Journal Article

BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES

Journal Article

Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Journal Article

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Journal Article

Self-supervised graph learning with target-adaptive masking for session-based recommendation

Yitong WANG, Fei CAI, Zhiqiang PAN, Chengyu SONG,wangyitong20@nudt.edu.cn,caifei08@nudt.edu.cn,panzhiqiang@nudt.edu.cn,songchengyu@nudt.edu.cn

Journal Article

Self-etching adhesives: possible new pulp capping agents to vital pulp therapy

Chun CUI, Xiu-Neng ZHOU, Wei-Min CHEN

Journal Article

Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey

N.V. Vasilyeva, E.R. Raush, M.V. Rudneva, T.S. Bogomolova, A.E. Taraskina, Yong Fang, Fengmin Zhang, N.N. Klimko

Journal Article

Coach-assisted multi-agent reinforcement learning framework for unexpected crashed agents

Jian ZHAO, Youpeng ZHAO, Weixun WANG, Mingyu YANG, Xunhan HU, Wengang ZHOU, Jianye HAO, Houqiang LI

Journal Article

preliminary version was presented at the 13th International Conference on Practical Applications of Agents

J. A. RINCON,J. BAJO,A. FERNANDEZ,V. JULIAN,C. CARRASCOSA

Journal Article

Safety issues of methylglyoxal and potential scavengers

Shiming LI, Siyu LIU, Chi-Tang HO

Journal Article